More specifically, the study, published Friday in the journal JAMA Network Open, found that the mortality rate from synthetic opioids in 28 states more than doubled every two years from 1999 to 2016. The District of Columbia saw the greatest increase in its opioid mortality rate, which more than tripled every year since 2013.
opioids killed more than 49,000 people in the United States in 2017
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